Isobutyraldehyde → HCID 21328735, compound

Participants

Reaction Steps

21.0 g (0.10 mol) of 2,2,6,6-tetramethyl-4-(isobutylideneamino)-piperidine (b.p. 42°-43°/0.05 mm Hg), obtained by condensation of an equimolecular mixture of 2,2,6,6-tetramethyl-4-aminopiperidine with isobutyraldehyde at 0°, and 13.8 g (0.10 mol) of diethyl phosphite and 0.02 g of sodium ethylate (dissolved in 0.3 ml of ethanol) are heated for 31/2 hours at 90°. The reaction product is dissolved in ether, washed with a saturated sodium chloride solution, dried over potassium carbonate and, after removal of the solvent by distillation, distilled (b.p. 133°/0.4 mm Hg). Diethyl-1-[(2,2,6,6-tetramethyl-4-piperidyl)-amino]-isobutyl-phosphonate is obtained in this manner.

Provenance & Evidence