HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 614286Generated: October 25, 2026
Methanol, 1,1-diethoxy-, 1-acetate → alpha-Carbethoxy-alpha-diethoxymethyl-beta-(3,4-dimethoxyphenyl)propionitrile
https://huagongshe.com/reaction/614286
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol, 1,1-diethoxy-, 1-acetate | HCID 84166 | — |
| Reactant | Ethyl 2-cyano-3-(3,4-dimethoxyphenyl)propanoate | HCID 12254388 | — |
| Product | alpha-Carbethoxy-alpha-diethoxymethyl-beta-(3,4-dimethoxyphenyl)propionitrile | HCID 12559142 | — |
Reaction Steps
A mixture of α-Carbethoxy-β-[3,4-dimethoxyphenyl]propionitrile (10 g) and diethoxymethyl acetate (30 g) was heated at 95° C. for 20 hours. The volatiles were removed under vacuum pump pressure leaving 13.4 g (94%) of a nearly colorless oil which solidified on standing at -5° C. to a white solid, m.p. 62°-65° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04144263 |
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| Source dataset | uspto-grants-1979_03 |
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| ORD ID | ord-93b65578415949a783ac1b5ef8037fe4 |
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| Source note | uspto-grants-1979_03 |
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