反应详情

Acetic anhydride (15.3 g., 0.15 mole) is added to a stirred suspension of 2-amino-4-methyl-6-benzyloxypyrimidine (23.6 g., 0.11 mole) in 150 ml of benzene. The mixture is heated at reflux for 4 hours. It is cooled, neutralized with aqueous sodium carbonate and the benzene layer separated. The benzene solution is concentrated under vacuum to an oil from which 2-acetamido-4-methyl-6-benzyloxy-pyrimidine melting at 121°-122° C. is isolated by crystallization from hexane n-butyl chloride.

1. temperatureThe mixture is heated
2. temperatureat reflux for 4 hours
3. temperatureIt is cooled
4. customthe benzene layer separated
5. concentrationThe benzene solution is concentrated under vacuum to an oil from which 2-acetamido-4-methyl-6-benzyloxy-pyrimidine melting at 121°-122° C.
6. customis isolated by crystallization from hexane n-butyl chloride