N-(2H-1,3-Benzodioxol-5-yl)-3-nitropyridin-2-amine → HCID 12445395, compound

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Reaction Steps

The crude nitro compound from Step A (11.5 g.) was hydrogenated in 175 ml. of methanol using 0.5 g. of 5% palladium on carbon as catalyst, the theoretical amount of hydrogen being consumed in 16 hours. The catalyst was removed on a filter. The filtrate was concentrated in vacuo and the dark residue was extracted with 75 ml. of 2.5 N hydrochloric acid and 75 ml. of water. The crude solution was used directly in the next step.

Provenance & Evidence