Hydrochloric Acid → 3-(2-Fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione

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Reaction Steps

3-Amino-2-(2-fluoroanilino)pyridine hydrochloride (3 g.) is dissolved in 25 ml. of 2.5 N hydrochloric acid and treated with 2 ml. of thiophosgene. After stirring 3 hours the mixture is clarified by filtration, and the filtrate is neutralized with ammonium hydroxide. The product separates and is recrystallized from methanol to give 1,3-dihydro-3-(2-fluorophenyl)imidazo[4,5-b]pyridin-2-thione.

Provenance & Evidence