Urea → HCID 54270804, compound

Participants

Reaction Steps

A mixture of 7.9 g. of the aminopyridine product of Step B and 25 g. of urea was heated in an oil bath at 185°-190° C. The reaction was kept at this temperature for 10 minutes then cooled and extracted with water. The crude product was extracted with 75 ml. of 2.5 N sodium hydroxide. The alkaline solution was treated with charcoal and excess acetic acid then was added to precipitate the product. The precipitate was purified by crystallization from dimethylformamide-ether.

Provenance & Evidence