Allyl bromide → HCID 21329311, compound

Participants

Reaction Steps

To a stirred suspension of 4.6 g. (0.016 mole) of the imidazopyridine product of Step C in 175 ml. of acetone, was added 1.8 g. (0.032 mole) of powdered potassium hydroxide. After stirring at room temperature for 20 minutes, 3.9 g. (0.032 mole) of allylbromide was added. Stirring at room temperature was continued overnight and the mixture then was concentrated to one-half volume. The concentrate was diluted with 150 ml. of water and the crude product was collected by filtration. The crude product was crystallized from 70 ml. of ethanol giving 2.0 g. of needles melting at 146°-148° C.

Provenance & Evidence