Ammonia → HCID 21329307, compound

HRID 614353Notes

Reaction equation

HRID 614353 reaction equation
[CH2:1]([N:4]1[C:12]2[C:7](=[N:8][C:9](Cl)=[CH:10][CH:11]=2)[N:6]([C:14]2[CH:19]=[CH:18][C:17]3[O:20][CH2:21][O:22][C:16]=3[CH:15]=2)[C:5]1=[O:23])[CH:2]=[CH2:3].[NH3:24]>>[CH2:1]([N:4]1[C:12]2[C:7](=[N:8][C:9]([NH2:24])=[CH:10][CH:11]=2)[N:6]([C:14]2[CH:19]=[CH:18][C:17]3[O:20][CH2:21][O:22][C:16]=3[CH:15]=2)[C:5]1=[O:23])[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 21329311HCID 21329311, compound

Product 1

HCID 21329307HCID 21329307, compound

Procedure

Heat a mixture of 2.5 g. of the imidazopyridin product of Step D and 25 ml. of liquid ammonia in a bomb at 150° C. for 3 hours. Remove the excess ammonia and crystallize the residue from dimethyl formide-water.

Workup

  1. temperatureHeat
  2. additiona mixture of 2.5 g
  3. customRemove the excess ammonia
  4. customcrystallize the residue from dimethyl formide-water

Sources & evidence

ORD record
ord-217bbb2a0478476d8d433a153e4bf0a5
Source dataset
uspto-grants-1979_03
Patent number
US04144341

Reaction notes

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