Ethyl chloroformate → HCID 21329316, compound

HRID 614354Notes

Reaction equation

HRID 614354 reaction equation
[CH2:1]([N:4]1[C:12]2[C:7](=[N:8][C:9](N)=[CH:10][CH:11]=2)[N:6]([C:14]2[CH:19]=[CH:18][C:17]3[O:20][CH2:21][O:22][C:16]=3[CH:15]=2)[C:5]1=[O:23])[CH:2]=[CH2:3].Cl[C:25]([O:27][CH2:28][CH3:29])=[O:26]>N1C=CC=CC=1>[CH2:28]([O:27][C:25]([C:9]1[N:8]=[C:7]2[N:6]([C:14]3[CH:19]=[CH:18][C:17]4[O:20][CH2:21][O:22][C:16]=4[CH:15]=3)[C:5](=[O:23])[N:4]([CH2:1][CH:2]=[CH2:3])[C:12]2=[CH:11][CH:10]=1)=[O:26])[CH3:29]

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 21329307HCID 21329307, compound

Product 1

HCID 21329316HCID 21329316, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Dissolve 1 g. of amino product produced in Example 35 in 20 ml. of dry pyridine. Cool in an ice-bath and stir while slowly adding 300 mg. of ethyl chloroformate. Allow the reaction mixture to stand at room temperature overnight. Pour the reaction mixture into ice-water and collect the crude product by filration. Crystallize the crude product from dimethyl formamide-ether.

Workup

  1. dissolutionDissolve 1 g
  2. temperatureCool in an ice-bath
  3. additionwhile slowly adding 300 mg
  4. customcollect the crude product by filration
  5. customCrystallize the crude product from dimethyl formamide-ether

Sources & evidence

ORD record
ord-9b0b878c16fd4aeb9f3faa84548fc3cf
Source dataset
uspto-grants-1979_03
Patent number
US04144341

Reaction notes

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