HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 614360Generated: October 26, 2026
Imidazole → 3-(N-imidazolyl)-2-nitrobenzofuran
https://huagongshe.com/reaction/614360
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Bromo-2-nitro-1-benzofuran | HCID 13509842 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(N-imidazolyl)-2-nitrobenzofuran | HCID 21329381 | — |
Reaction Steps
To a stirred solution of 0.1 g. (12 mmole) of imidazole in 20 ml. of N,N-dimethylformamide is added 0.5 g. (12 mmole) of 57.6 percent suspension of sodium hydride in mineral oil. After cooling to 20° C., 2.4 g. (10 mmole) of 3-bromo-2-nitrobenzofuran in 20 ml. of N,N-dimethylformamide is added. After stirring 45 minutes, the mixture is heated on a steam bath for 15 minutes, then 50 ml. of water are added. Cooling and filtration provide yellow needles of 3-(N-imidazolyl)-2-nitrobenzofuran, m.p. 147°-149° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04144347 |
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| Source dataset | uspto-grants-1979_03 |
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| ORD ID | ord-037d7bfbdbab438c8fdaaffe6a5cef9a |
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| Source note | uspto-grants-1979_03 |
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