Water → HCID 21329383, compound

HRID 614387Notes

Reaction equation

HRID 614387 reaction equation
[S:1]1[CH2:8][CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3][CH2:2]1.Cl.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19]N)=[CH:15][CH:14]=1.C([O-])(=O)C.[Na+].O>C(O)(=O)C>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]2[NH:19][C:5]3[CH2:4][CH2:3][CH2:2][S:1][CH2:8][CH2:7][C:6]=3[C:15]=2[CH:14]=1

Participants

6

Reactant 4

HCID 962WaterHCID 517045Sodium AcetateHCID 27239044-Methoxyphenylhydrazine hydrochlorideHCID 13346862HCID 13346862, compound

Product 1

HCID 21329383HCID 21329383, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 14.42g (0.1 mole) of 1-thiacyclooctane-5-one, 17.46g (0.1 mole) of p-methoxyphenylhydrazine hydrochloride and 8.21g (0.1 mole) of anhydrous sodium acetate in 170 ml of acetic acid is refluxed with stirring for five hours under nitrogen. The mixture is cooled and poured into 1 liter of water. On standing there is deposited a solid which after washing with water and recrystallization from methanol, gives 18.1g (74%) of an analytical sample, m.p. 122.5°-123.5° C.

Workup

  1. temperatureis refluxed
  2. temperatureThe mixture is cooled
  3. washafter washing with water and recrystallization from methanol
  4. customgives 18.1g (74%) of an analytical sample, m.p. 122.5°-123.5° C.

Sources & evidence

ORD record
ord-67dc585c3e3544b487f50a3c40a38a0e
Source dataset
uspto-grants-1979_03
Patent number
US04144349

Reaction notes

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