Hydrogen Bromide → 4-(4-Butyl-1-piperazinyl)phenol monohydrobromide

Participants

Reaction Steps

A mixture of 12.5 parts of 1-butyl-4-(4-methoxyphenyl)piperazine dihydrochloride and 150 parts of hydrobromic acid solution 48% in glacial acetic acid is stirred and refluxed overnight. The reaction mixture is evaporated and the residue is triturated in 2-propanone. The product is filtered off and crystallized from water, yielding 13.1 parts (81%) of 4-(4-butyl-1-piperazinyl)phenol monohydrobromide; mp. 281.9° C.

Provenance & Evidence