N,N-Dimethyl-1,3-propanediamine → N-[3-(Dimethylamino)propyl]-2-(2-oxopyrrolidin-1-yl)acetamide

HRID 614465Notes

Reaction equation

HRID 614465 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10]CC)=O.[CH3:13][N:14]([CH3:19])[CH2:15][CH2:16][CH2:17][NH2:18]>>[CH3:13][N:14]([CH3:19])[CH2:15][CH2:16][CH2:17][NH:18][C:8](=[O:10])[CH2:7][N:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1]

Participants

3

Reactant 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 109094Ethyl 2-oxopyrrolidine-1-acetate

Product 1

HCID 44374997N-[3-(Dimethylamino)propyl]-2-(2-oxopyrrolidin-1-yl)acetamide

Procedure

From 12.8 g. of ethyl 2-oxo-1-pyrrolidineacetate and 15.3 g. of 3-(dimethylamino)propylamine (U.S. Pat. No. 2,459,080), following the procedure of Example 1, there is obtained N-[3-(dimethylamino)propyl]-2-oxo-1-pyrrolidineacetamide; b.p. 157°-159° C./0.15 mm.

Sources & evidence

ORD record
ord-7749eb82c7dc4be69eda2a275b691b79
Source dataset
uspto-grants-1979_03
Patent number
US04145347

Reaction notes

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