N,N-Diethylethylenediamine → N-[2-(Diethylamino)ethyl]-2-(2-oxo-4-phenylpyrrolidin-1-YL)acetamide

HRID 614469Notes

Reaction equation

HRID 614469 reaction equation
[O:1]=[C:2]1[CH2:6][CH:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:4][N:3]1[CH2:13][C:14]([O:16]C)=O.[CH2:18]([N:20]([CH2:24][CH3:25])[CH2:21][CH2:22][NH2:23])[CH3:19]>>[CH2:18]([N:20]([CH2:24][CH3:25])[CH2:21][CH2:22][NH:23][C:14](=[O:16])[CH2:13][N:3]1[CH2:4][CH:5]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:6][C:2]1=[O:1])[CH3:19]

Participants

3

Reactant 2

HCID 60993N,N-DiethylethylenediamineHCID 13684993Methyl 2-oxo-4-phenyl-1-pyrrolidineacetate

Product 1

HCID 44374596N-[2-(Diethylamino)ethyl]-2-(2-oxo-4-phenylpyrrolidin-1-YL)acetamide

Procedure

From 7.0 g. of methyl 2-oxo-4-phenyl-1-pyrrolidineacetate and 5.0 g of 2-(diethylamino)ethylamine, following the procedure of Example 1, there is obtained N-[2-(diethylamino)ethyl]-2-oxo-4-phenyl-1-pyrrolidineacetamide in pure form as an oil, without need for distillation.

Sources & evidence

ORD record
ord-8dcd6f09a139460aba328bfba918bad2
Source dataset
uspto-grants-1979_03
Patent number
US04145347

Reaction notes

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