HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Pyrrolidineacetic acid, 2-methyl-5-oxo-, ethyl ester → cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-methyl-5-oxo-1-pyrrolidineacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Pyrrolidineacetic acid, 2-methyl-5-oxo-, ethyl ester | HCID 574476 | — |
| Reactant | 2-(cis-2,6-Dimethyl-1-piperidinyl)ethanamine | HCID 783702 | — |
| Product | cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-methyl-5-oxo-1-pyrrolidineacetamide | HCID 70610011 | — |
Reaction Steps
From 9.26 g. of ethyl 2-methyl-5-oxo-1-pyrrolidineacetate (British Pat. No. 1,309,692) and 8.6 g. of cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine, following the procedure of Example 9, there is obtained cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-methyl-5-oxo-1-pyrrolidineacetamide; m.p. 115°-116° C. after crystallization from cyclohexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04145347 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-88dc0e06b5634809b2f665ef092cad30 |
| Source note | uspto-grants-1979_03 |