HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(cis-2,6-Dimethyl-1-piperidinyl)ethanamine → cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-5,5-dimethyl-2-oxo-1-pyrrolidineacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(cis-2,6-Dimethyl-1-piperidinyl)ethanamine | HCID 783702 | — |
| Reactant | Ethyl 2,2-dimethyl-5-oxopyrrolidineacetate | HCID 21327791 | — |
| Product | cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-5,5-dimethyl-2-oxo-1-pyrrolidineacetamide | HCID 70609679 | — |
Reaction Steps
From 10 g. of ethyl 2,2-dimethyl-5-oxo-1-pyrrolidineacetate and 11 g. of cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine, following the procedure of Example 9, there is obtained cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-5,5-dimethyl-2-oxo-1-pyrrolidineacetamide as the hemihydrate; m.p. 94°-94.5° C. after recrystallization from isooctane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04145347 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-598508840ffa4da0adac05ffe4e0cd5b |
| Source note | uspto-grants-1979_03 |