Ethyl 2-oxopyrrolidine-1-acetate → N-[3-(2,2,4,6-tetramethyl-1-piperidinyl)propyl]-2-oxo-1-pyrrolidineacetamide

HRID 614482Notes

Reaction equation

HRID 614482 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10]CC)=O.[CH3:13][C:14]1([CH3:26])[CH2:19][CH:18]([CH3:20])[CH2:17][CH:16]([CH3:21])[N:15]1[CH2:22][CH2:23][CH2:24][NH2:25]>>[CH3:26][C:14]1([CH3:13])[CH2:19][CH:18]([CH3:20])[CH2:17][CH:16]([CH3:21])[N:15]1[CH2:22][CH2:23][CH2:24][NH:25][C:8](=[O:10])[CH2:7][N:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1]

Participants

3

Reactant 2

HCID 109094Ethyl 2-oxopyrrolidine-1-acetateHCID 213278113-(2,2,4,6-Tetramethyl-1-piperidinyl)propylamine

Product 1

HCID 44374688N-[3-(2,2,4,6-tetramethyl-1-piperidinyl)propyl]-2-oxo-1-pyrrolidineacetamide

Procedure

From 8.5 g. of ethyl 2-oxo-1-pyrrolidineacetate and 14 g. of 3-(2,2,4,6-tetramethyl-1-piperidinyl)propylamine (U.S. Pat. No. 3,446,811), following the procedure of Example 9, there is obtained N-[3-(2,2,4,6-tetramethyl-1-piperidinyl)propyl]-2-oxo-1-pyrrolidineacetamide; m.p. 85°-87° C. after recrystallization from ethyl ether.

Sources & evidence

ORD record
ord-d7be84c3af014a07ba400d9cd3379c88
Source dataset
uspto-grants-1979_03
Patent number
US04145347

Reaction notes

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