1-(3-Aminopropyl)-4-methylpiperazine → HCID 13594969, compound

HRID 614483Notes

Reaction equation

HRID 614483 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10]CC)=O.[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22][NH2:23])[CH2:16][CH2:15]1>>[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22][NH:23][C:8](=[O:10])[CH2:7][N:3]2[CH2:4][CH2:5][CH2:6][C:2]2=[O:1])[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 109094Ethyl 2-oxopyrrolidine-1-acetate

Product 1

HCID 13594969HCID 13594969, compound

Procedure

From 8.5 g. of ethyl 2-oxo-1-pyrrolidineacetate and 10.2 g. of 3-(4-methyl-1-piperazinyl)propylamine [J.A.C.S. 82, 2386 (1960)], following the procedure of Example 9, there is obtained N-[3-(4-methyl-1-piperazinyl)propyl]-2-oxo-1-pyrrolidineacetamide; m.p. 93° C. after recrystallization from cyclohexane.

Sources & evidence

ORD record
ord-28ec3777600046b09edbda82fa32bd0d
Source dataset
uspto-grants-1979_03
Patent number
US04145347

Reaction notes

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