Benzenamine, N,N-dichloro- → Benzenamine, 2,3-dichloro-, hydrochloride

2,3-dichloroaniline hydrochloride is prepared by 162 g of dichloroaniline being added slowly and with vigorous agitation to a mixture of 280 ml of acetic acid and 280 ml of concentrated (9 N) HCl, diazotization being effected by the addition of 75 g of NaNO2 dissolved in 150 ml of water, the temperature being maintained between 0° and 5° C. A mixture of 5 g of CaO and 60 ml of methacrolein (dissolved in 120 ml of acetone) and a solution of 6 g of CuCl dissolved in 60 ml of HCl are introduced simultaneously into the filtered diazonium salt solution over a period of 30 minutes. After the addition of the reagents the mixture is left to react at from 0° to 5° C. for 2 hours, then at from 10°-12° C. for 10 hours. The α-chloro-α-methyl-β-(2,3-dichlorophenyl)propionaldehyde is isolated similarly to the products in the previous examples. 206 g, corresponding to an 80% yield, of an oil distilling between 118° and 120° C. at a pressure of 0.01 mm Hg are obtained.

1. concentrationof concentrated (9 N) HCl, diazotization
2. additionbeing effected by the addition of 75 g of NaNO2
3. dissolutiondissolved in 150 ml of water
4. temperaturethe temperature being maintained between 0° and 5° C
5. additionA mixture of 5 g of CaO and 60 ml of methacrolein (dissolved in 120 ml of acetone)
6. dissolutiona solution of 6 g of CuCl dissolved in 60 ml of HCl
7. additionare introduced simultaneously into the filtered diazonium salt solution over a period of 30 minutes
8. additionAfter the addition of the reagents the mixture
9. waitis left
10. customto react at from 0° to 5° C. for 2 hours
11. distillation206 g, corresponding to an 80% yield, of an oil distilling between 118° and 120° C. at a pressure of 0.01 mm Hg
12. customare obtained

ORD record

ord-bf59185fec9d4bb88e445f5c1fec9607

Source dataset

uspto-grants-1979_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04145362