Acetic Acid → 5,6-Dimethoxy-3[4(tetrahydropyran-2-carbonyl) piperazinyl]methylene oxindole

HRID 614537Notes

Reaction equation

HRID 614537 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[NH:8][C:7](=[O:14])[C:6]2=[CH:15]O.[O:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]1[C:23]([N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)=[O:24].C(O)(=O)C>C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[NH:8][C:7](=[O:14])[C:6]2=[CH:15][N:28]1[CH2:29][CH2:30][N:25]([C:23]([CH:18]2[CH2:19][CH2:20][CH2:21][CH2:22][O:17]2)=[O:24])[CH2:26][CH2:27]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 20385082(Oxan-2-yl)(piperazin-1-yl)methanoneHCID 178486553HCID 178486553, compound

Product 1

HCID 538249585,6-Dimethoxy-3[4(tetrahydropyran-2-carbonyl) piperazinyl]methylene oxindole

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

5.00 g. of 5,6-dimethoxy-3-hydroxymethylene oxindole, 5,6 g. 1-(tetrahydropyran-2-carbonyl)piperazine and 2.1 g. acetic acid in 60 ml. benzene was reacted as described in Example 5 to give 6.18 g. of product, m.p. 208°-210° C.

Workup

  1. customto give 6.18 g

Sources & evidence

ORD record
ord-f814de0416214f6dae9ee879af0ff4b5
Source dataset
uspto-grants-1979_03
Patent number
US04145422

Reaction notes

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