HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl propiolate → 5,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl propiolate | HCID 12182 | — |
| Reactant | (3Z)-3-diazo-1H-indol-2-one | HCID 136455454 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 5,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carboxylic acid ethyl ester | HCID 136023344 | — |
Reaction Steps
A solution of 48 g (0.30 mole) of 3-diazooxindole and 38.7 g (0.39 mol) of ethyl propiolate in 2 l. of benzene is refluxed overnight. The reaction mixture is cooled to room temperature and the crude product filtered, wt.=60 g. Crystallization from absolute ethanol gives 54 g, m.p. 242°-244° (Sl. d.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04145420 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-e0840ca8861243e28c6588a3693f30bb |
| Source note | uspto-grants-1979_03 |