huagongshe.com
HRID61458

反应详情

EQUATION

反应方程式

HRID 61458 的结构方程式

REACTANTS

反应物

2
结构：CN1C[C@@H](OC(=O)N2CCCC2)C[C@H](C(=O)NO)[C@H]1C(=O)N1CC=C(c2ccccc2)CC1
HCID86598251

未命名化合物

结构：[H][H]
HCID178418361

未命名化合物

PRODUCTS

生成物

1
结构：CN1C[C@@H](OC(=O)N2CCCC2)C[C@H](C(=O)NO)[C@H]1C(=O)N1CCC(c2ccccc2)CC1
HCID86598250

未命名化合物

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O=S(=O)([O-])[O-].[Ba+2].[Pd]
催化剂HCID16218511

未命名化合物

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of (3S,5S,6S)-5-[(hydroxyamino)carbonyl]-1-methyl-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]piperidin-3-yl pyrrolidine-1-carboxylate (5.0 mg, 0.000011 mol) TFA salt in 1 mL of MeOH was hydrogenated in the presence of 5% Pd/BaSO4, under a balloon pressure of hydrogen, for 2 h. After filtered off the catalyst, the filtration was concentrated to dry to give the product (5.0 mg, 100%). MS (ESI): (M+H)+=459.15.

WORKUP

后处理

  1. filtrationAfter filtered off the catalyst
  2. filtrationthe filtration
  3. concentrationwas concentrated
  4. customto dry