反应详情

To a solution of diethyl 2-methyl-4-(2-thienyl)-6-formyl-1,4-dihydropyridine-3,5-dicarboxylate (940.68 mg) in 99% ethanol (30 ml) was gradually added sodium borohydride (113.5 mg) under stirring and this was further stirred at room temperature for 2 hours. After removal of ethanol, the residue was extracted with ethyl acetate and the extract was washed twice with water and then dried. The solvent was removed from the extract to give a pale yellow oil. The oil was pulverized with n-hexane. The powder was dissolved in ethyl acetate. After collecting by filtration of the insoluble product, to the filtrate was added n-hexane and the mixture was allowed to stand in refrigerator. The appearing crystals were collected by filtration to give pale yellow granules (857.2 mg) of diethyl 2-methyl-4-(2-thienyl)-6-hydroxymethyl-1,4-dihydropyridine-3,5-dicarboxylate, m.p. 125° to 126° C.

1. stirringthis was further stirred at room temperature for 2 hours
2. customAfter removal of ethanol
3. extractionthe residue was extracted with ethyl acetate
4. washthe extract was washed twice with water
5. customdried
6. customThe solvent was removed from the
7. extractionextract
8. customto give a pale yellow oil
9. filtrationAfter collecting by filtration of the insoluble product, to the filtrate
10. additionwas added n-hexane
11. filtrationThe appearing crystals were collected by filtration