Ammonia → HCID 21328264, compound

HRID 614630Notes

Reaction equation

HRID 614630 reaction equation
[C:1]([CH2:3][CH2:4][CH:5]1[CH2:10][C:9]([CH3:12])([CH3:11])[N:8]([CH3:13])[C:7]([CH3:15])([CH3:14])[CH:6]1[NH2:16])#[N:2].[H][H].N>CO.[Co]>[NH2:2][CH2:1][CH2:3][CH2:4][CH:5]1[CH2:10][C:9]([CH3:12])([CH3:11])[N:8]([CH3:13])[C:7]([CH3:15])([CH3:14])[CH:6]1[NH2:16]

Participants

6

Reactant 3

HCID 222AmmoniaHCID 23342303HCID 23342303, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 21328264HCID 21328264, compound

Reagents, catalysts & solvents 2

HCID 104730CobaltCatalystHCID 887MethanolSolvent

Procedure

100 parts of 4-(β-cyanoethyl)-amino-1,2,2,6,6-pentamethylpiperidine were dissolved in 500 parts of methanol and hydrogenated at a hydrogen pressure of 80 to 100 bar and a temperature of 80° to 100° C. with the addition of 150 parts of liquid ammonia and 25 parts of Raney cobalt until uptake of hydrogen ceased. The catalyst was removed by filtration and the filtrate was fractionated under vacuum. 95 parts of 4-(γ-aminopropyl)-amino-1,2,2,6,6-pentamethylpiperidine, boiling point 110° to 112° C./0.1 torr, were obtained.

Workup

  1. customThe catalyst was removed by filtration

Sources & evidence

ORD record
ord-0e429381cb5449f9a07509ec960de227
Source dataset
uspto-grants-1979_03
Patent number
US04145512

Reaction notes

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