Diazomethane → HCID 131711461, compound

Participants

Reaction Steps

7-(2-(2-Thienyl)acetamido)-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid (50 milligrams) in ethanol was reacted with excess diazomethane. After five minutes the excess diazomethane was evaporated and the desired methyl ester crystallized with ethanol, then with chloroform, and with acetone. Nine milligrams of the desired 7-(2-(2-thienyl)acetamido)-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid, methyl ester were obtained, m.p., 212°-214° C.

Provenance & Evidence