Nitric Acid → HCID 178433402, compound

Participants

Reaction Steps

A mixture of 330 parts of sulfuric acid (36 percent by weight), 100 parts of 2-methylimidazole, 50 parts of urea, 283 parts of nitric acid (31 percent by weight) and 153 parts of water is kept for 6.5 hours in a distillation vessel, equipped with a stirrer, at from 123° to 130° C. During the reaction, 20 parts of 30 percent strength by weight nitric acid distill off. The reaction mixture is then diluted with a 3.5-fold volume of water whilst cooling and is neutralized to pH 3-4 with ammonia solution. The 2-methyl-4-nitroimidazole which separates out is centrifuged off, washed, dried and recrystallized from water. 138 parts of 2-methyl-4-nitroimidazole (89.0% of theory) of melting point 145°-146° C. are obtained.

Provenance & Evidence