Nitric Acid → HCID 178433402, compound

Participants

Reaction Steps

A mixture of 3,735 parts of sulfuric acid (35.5 percent by weight), 1,135 parts of 2-methylimidazole, 565 parts of urea, 3,495 parts of nitric acid (33 percent by weight) and 1,625 parts of water is reacted continuously in a three-stage cascade (consisting of 3 reactors each with a distillation column and reflux condenser) for 6 hours at from 125° to 130° C. During the reaction, 2,088 parts of 33 percent strength by weight nitric acid distil off. The reaction mixture is then diluted with a 3.5-fold volume of water whilst cooling and is neutralized to pH 3-4 with ammonia solution. The 2-methyl-4-nitroimidazole which separates out is centrifuged off, washed, dried and recrystallized from water. 1,475 parts of 2-methyl-4-nitroimidazole (83.5% of theory) of melting point 145°-146° C. are obtained.

Provenance & Evidence