Hydrochloric Acid → HCID 12682411, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 400 grams (1.42 moles) of diethyl 1-methyl-3,3-diethoxypropylphosphonate in 1 liter of water and 4 liters of acetone containing 30 ml of concentrated hydrochloric acid was stirred and refluxed under nitrogen at 62° C. for 1.5 hours. Low boiling materials were removed at 80° C./16 mm to give the diethyl 1-methyl-3-oxopropylphosphonate in a 296 grams (quantitative) yield as a pale yellow liquid. The structure was confirmed by NMR.

Provenance & Evidence