HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 23346166, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-[(Thiazol-2-yl)methylthio]ethylamine | HCID 12923403 | — |
| Reactant | 5-(4-Chlorobenzyl)-2-methylthiopyrimid-4-one | HCID 12945980 | — |
| Product | HCID 23346166 | HCID 23346166 | — |
Reaction Steps
An intimate mixture of 5-(4-chlorobenzyl)-2-methylthio-4-pyrimidone (1.36 g) and 2-(2-thiazolylmethylthio)ethylamine (0.9 g) was heated at 130°-135° for 31/2 hours. After cooling the reaction mixture was treated with 2N hydrochloric acid. Evaporation to dryness followed by recrystallisation from isopropanol/methanol gave 2-[2-(2-thiazolyl-methylthio)-ethylamino]-5-(4-chlorobenzyl)-4-pyrimidone monohydrochloride, m.p. 172.5°-174.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04145546 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-0d1ff918fdfd4cdea1c59a34d1195898 |
| Source note | uspto-grants-1979_03 |