Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl malate → 2-(2-Fluorobenzyloxy)-butane-1,4-dicarboxylic acid dimethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl malate | HCID 12674 | — |
| 반응물 | alpha-Bromo-o-fluorotoluene | HCID 67968 | — |
| 촉매 | Silver(II) oxide | HCID 92152 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 2-(2-Fluorobenzyloxy)-butane-1,4-dicarboxylic acid dimethyl ester | HCID 53817045 | 131.4% |
반응 단계
46.4 g (0.2 mol) of silver oxide were added in portions, with constant stirring, to a mixture of 16.2 g (0.1 mol) of malic acid dimethyl ester and 57 g (0.30 mol) of 2-fluorobenzyl bromide. An exothermic reaction started slowly, and the temperature rose to 80° C. After cooling, 200 ml of ether were added, the solid was filtered off, the filtrate was concentrated and the residue was distilled at 180° C. in a waterpump vacuum. 19.6 g (72.6% of theory) of 2-(2-fluorobenzyloxy)-butane-1,4-dicarboxylic acid dimethyl ester were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04146384 |
| 출처 데이터셋 | uspto-grants-1979_03 |
| ORD ID | ord-ea16179e746c48efbbe5562a88865ebe |
| 출처 메모 | uspto-grants-1979_03 |