HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 2-Tetrazoline-5-thione, 1-(hydroxymethyl)-4-phenyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | HCID 15291093 | HCID 15291093 | — |
| Reactant | HCID 86736426 | HCID 86736426 | — |
| Reactant | 1-phenyltetrazole-5-thiol | HCID 178527986 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Tetrazoline-5-thione, 1-(hydroxymethyl)-4-phenyl- | HCID 208599 | — |
Reaction Steps
1-Phenyl-4-hydroxymethyltetrazolin-5-thione which was prepared from 1-phenyl-5-mercaptotetrazole and an excess amount of formaldehyde was reacted with 2 to 5 times on a molar basis of thionyl chloride in benzene at 50° C. for 3 hours to prepare 1-phenyl-4-chloromethyltetrazolin-5-thione. This was reacted with an equimolar amount of 1,4-dihydroxy-N-(2-tetradecyloxy)-phenylnaphthamide in DMF in the presence of 1.5 to 3 times on a molar basis of sodium ethoxide to obtain Coupler (42).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04146396 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-93c2ed129dcb47a3b98202638c6070c6 |
| Source note | uspto-grants-1979_03 |