Acetic Anhydride → HCID 54510168, compound

Participants

Reaction Steps

Benzyl O-benzylthreonylvalylleucinate is prepared from 1 gram of benzyl O-benzylthreonylvalylleucinate hydrochloride as in Example 5 and is dissolved in acetic acid, and 2 equivalents acetic anhydride based on the benzyl ester are added. The mixture is stirred overnight. The solvents are evacuated in vacuo. The residue is recrystallized from methanol/ether, to yield 806 milligrams of benzyl N-α-acetyl-O-benzylthreonylvalylleucinate (85% yield).

Provenance & Evidence