2-[(Acetylsulfanyl)methyl]-5-aminopentanoic acid → 5-Amino-2-mercaptomethylpentanoic acid
Reaction equation
C([S:4][CH2:5][CH:6]([CH2:10][CH2:11][CH2:12][NH2:13])[C:7]([OH:9])=[O:8])(=O)C>O.N>[NH2:13][CH2:12][CH2:11][CH2:10][CH:6]([CH2:5][SH:4])[C:7]([OH:9])=[O:8]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
2-Acetylthiomethyl-5-aminopentanoic acid (1 g.) is dissolved in a mixture of water (12 ml.) and concentrated ammonia (12 ml.) under a blanket of argon. The solution is stored for twenty minutes at room temperature and concentrated to dryness in vacuo. The residue is applied to a column of Dowex 50 in the hydrogen cycle, the column is washed with water and 5-amino-2-mercaptomethylpentanoic acid is eluted with 2M pyridine-acetate buffer pH 6.5.
Workup
- waitThe solution is stored for twenty minutes at room temperature
- concentrationconcentrated to dryness in vacuo
- washthe column is washed with water and 5-amino-2-mercaptomethylpentanoic acid
- washis eluted with 2M pyridine-acetate buffer pH 6.5
Sources & evidence
- ORD record
- ord-5ff74b1447954cb0a05f6c3fea4fd550
- Source dataset
- uspto-grants-1979_03
- Patent number
- US04146611
Reaction notes
Loading…