HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Acetylthio-5-benzyloxycarbonylaminopentanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Thiopheneacetic acid | HCID 15970 | — |
| Reactant | 5-{[(Benzyloxy)carbonyl]amino}-2-bromopentanoic acid | HCID 20384311 | — |
| Solvent | Potassium Carbonate | HCID 11430 | — |
| Product | 2-Acetylthio-5-benzyloxycarbonylaminopentanoic acid | HCID 20384314 | — |
Reaction Steps
Thiolacetic acid (1 g.) is added to a solution of 5-benzyloxycarbonylamino-2-bromopentanoic acid [Chem. Pharm. Bull., 24, 326 (1976)] (3.3 g.) in a mixture of water (30 ml.) and potassium carbonate (1.38 g.). The mixture is stirred at room temperature overnight, acidified and extracted with ethyl acetate to yield 2-acetylthio-5-benzyloxycarbonylaminopentanoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04146611 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-7c2d4e135e5a49a19003ed4940e607b5 |
| Source note | uspto-grants-1979_03 |