HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane → 1-Methyl-4-phenyl-4-azido-3-hydroxypiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 3-Methyl-6-phenyl-7-oxa-3-azabicyclo[4.1.0]heptane | HCID 435091 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Methyl-4-phenyl-4-azido-3-hydroxypiperidine | HCID 21327206 | — |
Reaction Steps
1.4 G. of sodium azide (NaN3) in 6 ml. of water was added to a solution of 3.6 g. of 1-methyl-4-phenyl-3,4-epoxypiperidine in 20 ml. of dioxane and the resulting combined solution refluxed for two hours. A further portion of 1.4 g. of NaN3 in 6 ml. of water was then added and the reaction mixture refluxed overnight. Upon cooling 3.2 g. of crystals of the dresired 1-methyl-4-phenyl-4-azido-3-hydroxypiperidine were obtained, which had a melting point of 170°-71° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04146629 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-8ca564d968d14d208cec8cab25f53c2c |
| Source note | uspto-grants-1979_03 |