Hydrogen Bromide → HCID 178419687, compound

Participants

Reaction Conditions

Reaction Steps

Acetic acid (100 ml) was saturated with hydrogen bromide at 10° C. and the mixture was treated with 5-benzyloxycarbonylamino-2-hydroxy-N-(tetrazol-5-yl)benzamide (1.77 g). The mixture was stirred at 25° C. for 20 hours, and then most of the hydrogen bromide was removed by passing a stream of air through the mixture for 6 hours. Any finely divided suspended solid was then removed by centrifuging and the supernatant liquid was decanted off. Removal of the acetic acid in vacuo gave a solid, which was triturated with diethyl ether and dried to give 5-amino-2-hydroxy-N-(tetrazol-5-yl)benzamide hydrobromide (1.0 g), m.p. above 330° C.

Provenance & Evidence