HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-Hydroxy-3-(4-phenoxymethylpiperidino)-propoxy-2-ethoxycarbonylindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 4-hydroxy-1H-indole-2-carboxylate | HCID 13274763 | — |
| Reactant | N-(2,3-epoxypropyl)-4-phenoxymethylpiperidine | HCID 21327287 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Hydroxy-3-(4-phenoxymethylpiperidino)-propoxy-2-ethoxycarbonylindole | HCID 86736429 | — |
Reaction Steps
A mixture of 0.9 g. 2-ethoxycarbonyl-4-hydroxyindole, 1.7 g. N-(2,3-epoxypropyl)-4-phenoxymethylpiperidine, 1.2 g. potassium carbonate and 50 ml. acetonitrile is heated under reflux for 10 hours. The reaction mixture is then filtered while still hot and the filtrate left to cool overnight. 0.3 g. (15% of theory) 4-[2-hydroxy-3-(4-phenoxymethylpiperidino)-propoxy]-2-ethoxycarbonylindole crystallize out; m.p. 168°-170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04146630 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-4883bb9787fb4ac084753e960ec14d99 |
| Source note | uspto-grants-1979_03 |