Hydrochloric Acid → HCID 21327260, compound

Participants

Reaction Steps

A solution of 28.0 g. 2-amino-3-nitro-1-[3-(4-phenoxymethylpiperidino)-propoxy]-benzene hydrochloride in 600 ml. ethanol and 200 ml. water is hydrogenated at ambient temperature and atmospheric pressure in the presence of 0.4 g. platinum oxide. After filtration, the filtrate obtained is acidified with dilute hydrochloric acid, evaporated and the evaporation residue dissolved in ethanol/ethyl acetate. There are obtained 21.4 g. (70% of theory) 2,3-diamino-1-[3-(4-phenoxymethylpiperidino)-propoxy]-benzene trichloride in the form of an amorphous salt.

Provenance & Evidence