Potassium Carbonate → HCID 21327264, compound

Participants

Reaction Steps

A mixture of 24 g. 2-benzyl-4-hydroxyindazole, 10.4 ml. 3-bromopropan-1-ol and 16 g. potassium carbonate in 100 ml. dimethylformamide is stirred for 30 hours at 70° C. After dilution with methylene chloride, the reaction mixture is filtered with suction, the filtrate is evaporated and the evaporation residue is purified chromatographically on silica gel (elution agent methylene chloride-ethyl acetate 9:1 v/v), 2-benzyl-4-(3-hydroxypropoxy)-indazole being obtained in the form of an oil.

Provenance & Evidence