Acetic Acid → HCID 54133016, compound

Participants

Reaction Steps

39.05 g of (S)-3-ethyl-3-diethoxymethyl-1-[2-(5-fluoro-indol-3-yl)-ethyl]-2-piperidone are mixed with 80 cc of 99% acetic acid and 20 cc of water. The mixture is heated to the boil for half an hour in an atmosphere of nitrogen. After cooling, the solvent is removed by evaporation; the oily residue is subsequently taken up twice in 50 cc amounts of toluene and again concentrated by evaporation in order to remove most of the water and acetic acid. After crystallization from ethyl acetate/hexane (1:2) at 0°, brownish crystals are obtained. M.P. 116°, [α]D20 = -31.5° (1%, CHCl3).

Provenance & Evidence