Acetic Anhydride → HCID 21327447, compound

HRID 614863Notes

Reaction equation

HRID 614863 reaction equation
[Cl:1][C:2]([Cl:10])([Cl:9])[CH:3]([NH:7][CH3:8])[NH:4][CH:5]=[O:6].C(O[C:15](=[O:17])[CH3:16])(=O)C>>[Cl:1][C:2]([Cl:10])([Cl:9])[CH:3]([NH:4][CH:5]=[O:6])[N:7]([CH3:8])[C:15](=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 21327444HCID 21327444, compound

Product 1

HCID 21327447HCID 21327447, compound

Procedure

A mixture of 1,1,1-trichloro-2-methylamino-2-formamidoethane (6.85g) and acetic anhydride (17ml) was heated on a water bath for 11/2 hours. The reaction mixture was concentrated to give a oily residue which was triturated with water. The solid formed was collected, washed with water and dried (3.6g). Recrystallisation from benzene gave pure 1,1,1-trichloro-2-formamido-2-(N-methylacetamido)ethane (3.2g, m.p. 126-8)

Workup

  1. temperaturewas heated on a water bath for 11/2 hours
  2. concentrationThe reaction mixture was concentrated
  3. customto give a oily residue which
  4. customwas triturated with water
  5. customThe solid formed
  6. customwas collected
  7. washwashed with water
  8. customdried (3.6g)
  9. customRecrystallisation from benzene

Sources & evidence

ORD record
ord-616b978487a34ddf89af00e8da359715
Source dataset
uspto-grants-1979_03
Patent number
US04146646

Reaction notes

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