Cyanoacetamide → HCID 54297024, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of cyanoacetamide (84 g.), triethylorthopropionate (193 g.) and morpholine (108 g.) was heated under reflux for 3 hours. The initial reflux temperature was 121° C. and the final reflux temperature was 91° C. At the end of the reflux period acetonitrile (50 ml.) was added, the mixture was cooled to 25° C., the crystalline precipitate was collected, and washed with 2 × 100 ml. of cold ethanol. Weight = 87 g. Yield = 42%. A sample was recrystallized from ethanol as white needles m.p. 158° C.

Provenance & Evidence