反应详情

温度

190 °C

A mixture of 1.63 g of 2-tetrahydrofurfurylamino-5-nitrobenzophenone, 3.0 g of ethyl carbamate and 0.2 g of zinc chloride was heated at 190° C. (oil bath temperature) for 2 hours. After cooling, the reaction mixture was dissolved in chloroform and the insoluble material was filtered off. The chloroform solution was washed successively with dilute hydrochloric acid and water, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure and the residue was washed with ether. The insoluble product was collected by filtration and dried to give 1-tetrahydrofurfuryl-4-phenyl-6-nitro-2(1H)-quinazolinone, m.p. 150°-152° C.

1. temperatureAfter cooling
2. filtrationthe insoluble material was filtered off
3. washThe chloroform solution was washed successively with dilute hydrochloric acid and water
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvent was removed under reduced pressure
6. washthe residue was washed with ether
7. filtrationThe insoluble product was collected by filtration
8. customdried