Triethylamine → HCID 21327522, compound

Participants

Reaction Steps

A mixture of 2.36 g of 2-(N-tetrahydrofurfuryltrichloroacetamido)-5-nitrobenzophenone, 2.4 g of ammonium acetate, 0.5 g of triethylamine and 30 ml of tertiary butanol was stirred under reflux for 10 hours. Then the solvent was removed and water was added to the residue. The resulting mixture was extracted with chloroform and the extract was washed successively with dilute ammonia water and water, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure. The residue was washed with ether and the insoluble product was collected by filtration and dried to give 1-tetrahydrofurfuryl-4-phenyl-6-nitro-2(1H)-quinazolinone, m.p. 150°-152° C.

Provenance & Evidence