反应详情

2-Chloro-9-(2-hydroxyethoxymethyl)adenine (0.83g) was added with stirring to 95% hydrazine (11ml) and the resulting solution stirred 1 hour under nitrogen. Excess hydrazine was removed by distillation in a rotary evaporator at a bath temperature of 30° C. followed by co-evaporation twice with ethyl acetate. The residue was thoroughly triturated with methanol to give a quantitative yield (0.8g) of white to cream colored-2-hydrazino-9-(2-hydroxyethoxymethyl)adenine, m.p. 220°-222° C.

1. customExcess hydrazine was removed by distillation in a rotary evaporator at a bath temperature of 30° C.
2. customThe residue was thoroughly triturated with methanol