反应详情

温度

125 °C

A mixture of 2-chloro-9-(2-hydroxyethoxymethyl) hypoxanthine (0.375g) and methanol (80ml) saturated with anhydrous ammonia was heated in a bomb at 125° C. for 5 hours. The bomb was cooled in an ice bath and the reaction mixture removed. Solvent and excess ammonia were removed under reduced pressure at 50° C. After the residue was triturated with cold water to remove the ammonium chloride formed, the remaining solid was dried and then recrystallized from methanol to give pure 9-(2-hydroxyethoxymethyl)guanine (0.24g), m.p. 256.5°-257° C.

1. temperatureThe bomb was cooled in an ice bath
2. customthe reaction mixture removed
3. customSolvent and excess ammonia were removed under reduced pressure at 50° C
4. customAfter the residue was triturated with cold water
5. customto remove the ammonium chloride
6. customformed
7. customthe remaining solid was dried
8. customrecrystallized from methanol