反应详情

9-(benzoyloxyethoxymethyl)guanine (0.58g) and methanol (80ml) saturated with ammonia were heated in a bomb at 80° C. for 16 hours. The reaction mixture was removed from the bomb and the solvent evaporated under reduced pressure. The residue was thoroughly washed with ether and then recrystallized from methanol to give 9-(2-hydroxyethoxymethyl)guanine (0.31g., 75% of theoretical), m.p. 256.5°-257° C.

1. customThe reaction mixture was removed from the bomb
2. customthe solvent evaporated under reduced pressure
3. washThe residue was thoroughly washed with ether
4. customrecrystallized from methanol