反应详情

A solution of 2-amino-9-(2-hydroxyethoxymethyl)adenine (0.5 g) in 97% formic acid (2.5 ml) was stirred in an ice bath for 3 hours, and then at room temperature overnight. Dry ether (80 ml) was added and the mixture chilled. The solid was removed by filtration and dissolved in hot acetonitrile (125 ml); residual solids were removed by filtration. The filtrate was applied to a column containing silica gel (14 g) in acetonitrile. The column was eluted with dry acetone. The eluate was evaporated and the residual solid recrystallized from acetonitrile to give 2-amino-9-(2-formyloxyethoxymethyl)adenine (93 mg, m.p. 238°-240° C.).

1. customat room temperature
2. customovernight
3. temperaturethe mixture chilled
4. customThe solid was removed by filtration
5. dissolutiondissolved in hot acetonitrile (125 ml)
6. customresidual solids were removed by filtration
7. additioncontaining silica gel (14 g) in acetonitrile
8. washThe column was eluted with dry acetone
9. customThe eluate was evaporated
10. customthe residual solid recrystallized from acetonitrile