反应详情

温度

190 °C

A suspension of 3.0 g of 9-fluoro-11β-hydroxy-17,17-bis(phenylthio)androsta-1,4-dien-3-one in 150 ml of diethylbenzene is stirred at 190° C. for 45 minutes. The solution is cooled at 0° C. and a solid crystallizes. This is filtered and dried in vacuo to give 2.3 g of material. Recrystallization from chloroform-methanol gives 1.1 g of the title compound, melting point 250°-251° C. (dec.).

1. temperatureThe solution is cooled at 0° C.
2. customa solid crystallizes
3. filtrationThis is filtered
4. customdried in vacuo