Potassium Hydroxide → HCID 16785921, compound

HRID 615003Notes

Reaction equation

HRID 615003 reaction equation
C([O:3][C:4](=[O:20])[CH2:5][C:6]1[C:7]([CH3:19])=[N:8][N:9]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)[C:10]=1[CH3:11])C.[OH-].[K+]>O.C(O)C>[CH3:19][C:7]1[C:6]([CH2:5][C:4]([OH:20])=[O:3])=[C:10]([CH3:11])[N:9]([C:12]2[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[N:8]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 53904691HCID 53904691, compound

Product 1

HCID 16785921HCID 16785921, compoundYield 82%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

8.2 grams of the 3,5-dimethyl-1-(p-tolyl)pyrazol-4-acetic acid-ethyl ester, produced by the method of Example (4a), were mixed with a solution of 2.5 grams potassium hydroxide in 15 milliliters water and 15 milliliters ethanol, and the ester saponified and the free acid isolated by the method described in Example (1b). 6.0 grams of 3,5-dimethyl-1-(p-tolyl)-pyrazol-4acetic acid, melting at 119°-121° C. were obtained, representing a yield of 82%.

Workup

  1. customthe free acid isolated by the method

Sources & evidence

ORD record
ord-14da03826de448eabd93713fe92c194c
Source dataset
uspto-grants-1979_03
Patent number
US04146721

Reaction notes

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